ea0059p175 | Obesity & metabolism | SFEBES2018
Milona Alexandra
, Willemsen Ellen
, Artigas Natalia
, Paterson Helen
, Vos Harmjan
, Naik Jyoti
, Miguel-Aliaga Irene
, Bosma Piter
, Burgering Boudewijn
, Williamson Catherine
, Vernia Santiago
, Mil Saski van
, Owen Bryn
Coupling metabolic processes to nutrient availability is essential for survival. The nuclear receptors PPARĪ± and FXR regulate adaptive liver metabolism in the fasted-state and fed-state, respectively, through a complex mechanism that is incompletely understood. Here, we show that hepatic expression of the steroidogenic enzyme Cyp17al is strikingly regulated by feed-fast cycles via a repressive nuclear receptor cascade involving bile-acid:FXR signalling. Using both gain- a...